Friday, July 25, 2014

Best Post of January 2014 -- The Alzheimer Conundrum: New Book Challenges Long-Held Assumptions

Margaret Lock, PhD
The next in our Best of the Month series comes from January 16, 2014: 
Professor Margaret Lock supplies an ethnographic account of Alzheimer disease in her recent book, The Alzheimer Conundrum. Lock furnishes a comprehensive description of the events leading up to the recasting of the phenomenon of Alzheimer’s as a condition to be prevented. The author challenges traditional assumptions and statistics about Alzheimer’s and takes us on a journey from the disease’s original clinical case through the vacillations in the science world and the media regarding possible causes, diagnostics, biomarkers, genetics and cures. She questions prevalence estimates for the impending “Alzheimer’s epidemic” that has been forecast with great assurance by some interest groups. Lock raises provocative questions that extend beyond the realm of Alzheimer disease, such as: When is a disease not a disease? When is pathology normal? When does a natural entity become pathological? Worth a read for those of us who are charged with the responsibility of ultimately diagnosing Alzheimer disease at autopsy.

Wednesday, July 16, 2014

"In a decade, the only people who are still playing football will be African-Americans and working class people." - Sociologist Harry Edwards

Harry Edwards, PhD
The public health policy debate (in which neuropathologists are inevitably enmeshed by virtue their involvement in the diagnosis of chronic traumatic encephalopathy) has taken on a new socio-economic ramification. I was reading an article this morning about NFL-player DeSean Jackson in the July 7th issue of ESPN The Magazine when I came across a provocative insight from sociologist Harry Edwards based on recent studies showing that white families and wealthier families are more informed about football-related concussions than their non-white and poor counterparts. Edwards had this to say about the changing demographics of football: "In a decade, the only people who are still playing football will be African-Americans and working class people."  Just as boxing was once embraced by Ivy League athletes but in recent decades dismissed as barbaric, football will one day be relegated to the underclass and only appreciated as a spectator sport among middle-class white people. Unsettling, isn't it?

Tuesday, July 8, 2014

Best Post of December 2013: What Happened to Neuropathology in 1946

The next in our 'Best of the Month' series is from December 3, 2013. Since posting, three readers posted comments speculating as to what indeed did happen to neuropathology in 1946. See comments after the post below:

What happened to neuropathology in 1946?

The esteemed Dr. Jim Mandell and his son were recently playing with the amazing Google Books Ngram Viewer. Google Ngram searches a huge corpus of books for the mention of a particular search term. It then graphs the frequency with which that term appears over time. On a whim, the Mandell's entered the search term "neuropathologist". Here's the resulting graph:

I couldn't fit the y-axis label in the picture, but it ranges from 0% up to 0.00000300%. Dr. Mandell challenges his neuropathology colleagues to explain the sharp spike in the usage of "neuropathologist" around 1946-47. Please enter your speculations in the comment section. Dr. Mandell also points out the lamentable fact that it "appears we are past our peak".
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Gabrielle Yeaney said...
Not sure if I'm on to something but ...in 1946--certification in pathology was formally recognized, CAP was founded and in 1947--first stereotactic neurosurgical procedure performed. In the early 1940s, AMA recognized pathology as practice of medicine (1943);first neurosurgical training programs and American board of Neurological surgery established. Bernd Scheithauer was born in 1946. Maybe he started publishing at a very early age :) Thanks for the blog
jd said...
JNEN began in 1942.
shipcolldoc said...
It is likely just because WW II was over and a lot of medicine-related terminology other than war trauma would have come to the fore.

Wednesday, July 2, 2014

3D print of white matter "captures a sense of delicate complexity that evokes a sense of wonder about the brain"

Creating an accurate 3D model of the brain's white matter for Philadelphia's Franklin Institute was a project no 3D printing company would tackle -- until 3D Systems (Rock Hill, SC) agreed to take it on. Here is an image of the finished project, which took about 210 hours to print out:

Interviewed for the tech website CNET, Franklin Institute chief bioscientist and lead exhibit developer Dr Jayatri Das said that the model "has really become one of the iconic pieces of the exhibit. Its sheer aesthetic beauty takes your breath away and transforms the exhibit space," said . "The fact that it comes from real data adds a level of authenticity to the science that we are presenting. But even if you don't quite understand what it shows, it captures a sense of delicate complexity that evokes a sense of wonder about the brain."

Thanks to the illustrious Dr. Doug Shevlin for informing me of this remarkable feat of engineering which, in his words, sits at "the intersection of neuroscience, computers and 3D printing".

Wednesday, June 25, 2014

2nd Edition of "Biopsy Diagnosis of Peripheral Neuropathy" to be released August 31, 2014

The second edition of Biopsy Diagnosis of Peripheral Neuropathy by Drs. Juan M. Bilbao and Robert E. Schmidt is set to come out on August 31, 2014. The is from the book's description from amazon.com:
"This book presents a simple, logical method for constructing a differential diagnosis based on pathology and clinical presentation. It also provides advice on the selection of ancillary molecular, immunohistochemical and genetic techniques to establish a definitive diagnosis. Clear, authoritative guidance is offered on diagnosis of the full range of neuropathies with the aid of a wealth of high-quality color photomicrographs and electron micrographs. The pathologist will benefit greatly from the identification of a variety of artifacts and normal structures occasionally encountered in nerve biopsies that need to be distinguished from specific pathologic alterations"


The first edition, also co-authored by Bilbao, was released back in 1995. Given the advent of new diagnoses and techniques of analysis and the impact of molecular genetics, there is without doubt a dire need for this book, which is authored by well-established authorities in the field.

Thanks to the inimitable Dr. Mark Cohen for alerting me to the imminent release of this text.

Monday, June 16, 2014

Horbinski Group develops online tool to estimate likelihood of IDH1/2 mutation in a glioma

Craig Horbinski, MD, PhD.
The illustrious Craig Horbinski, MD, PhD wrote in to share a link to an online tool which his team developed which helps triage brain tumor cases that might benefit from additional molecular testing.   Here's what the University of Kentucky neuropathologist had to say about this new website: "We have developed an online-based tool to provide a statistical estimate of the likelihood of an IDH1/2 mutation in a glioma, based
on a few easily-obtained parameters. Several variables like patient age, WHO grade, etc. are well-known to correlate with mutations, but no formula has yet been developed that synthesizes those variables into one unified probability score. An added feature is that it generates separate scores if no testing has been done at all, and if R132H IDH1 immunostain was done but is negative. Hopefully this will help pathologists and investigators better triage cases that would benefit from additional testing, both in clinical and in research endeavors."

Thanks, Craig!

Monday, June 9, 2014

Rocky Report from Columbia, MO

Dispatch from University of Missouri Neuropathologist Douglas C. Miller, MD, PhD:
"I saw this rock today while out walking for exercise. To me it looks like half an axially cut midbrain. No PD here!"